- "What has eight heads, fries enemies on sight and laughs maniacally? Yes! I'm looking at you, holding at you, holding this beast of a gun! As far as I'm concerned, hundreds of demons were harmed in the process of making this weapon. But let's be serious - who gives a rat's ass about that? I don't really know how this thing works but... damn, son... it's Medusa's freaking head! Just press 'FIRE' to feel like a real Spartan!"
- —In-game description.
A reward for bounty-hunting mission, Toxic Avengers.
Medusa Ray is a glove lance hardlocked to acid. That makes it a counterpart of Feuerfaust and Emperor's Touch, but sadly it does not stack well to either of them. Acid ray it makes is for some inexplicable reason much harder to aim than fire ray of Feuerfaust and lacks the self-guiding nature of electrical arcs from Emperor`s Touch.
Damage radius is biggest out of all lances, but utilizing it properly is finicky and special effect is rather lackluster.
- The weapon is modelled after the gorgon named Medusa, a monster appearing as a human female with living venomous snakes in place of hair and the lower body of a snake with a gaze that turns anyone to stone.
- The in-game description references 1981 film Clash of the Titans.